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Fondazione
Callerio Onlus
Istituti di Ricerche Biologiche
RELAZIONE
SCIENTIFICA 2001
DOCUMENTAZIONE DEI RISULTATI
[1
luglio 2000 - 30 giugno 2001]
I risultati scientifici
ottenuti sono stati oggetto di pubblicazione
su riviste specialistiche, in prevalenza
a carattere internazionale, e sono stati
presentati a convegni e congressi sia nazionali
sia internazionali come di seguito elencato.
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|
LAVORI
SCIENTIFICI SU RIVISTA SPECIALISTICA |
| 1) |
Sava G, Bergamo A.
Ruthenium-based compounds and tumour
growth control
(Review). Int. J. Oncol., 17:
353-365, 2000.
|
| 2) |
Magnarin M, Bergamo A, Carotenuto ME,
Zorzet S, Sava G.
Increase of tumour infiltrating lymphocytes
in mice treated with antimetastatic
doses of NAMI-A.
Anticancer Res., 20: 2939-2944,
2000.
|
| 3)
|
Alessio
E, Iengo E, Zorzet S, Bergamo A, Coluccia
M, Boccarelli A, Sava G.
Antimetastatic properties and DNA interactions
of the novel class of dimeric Ru(III)
compounds Na2[[(trans-RuCl4(Me2SO)]2(mu-L)]
(L= ditopic, non-chelating aromatic
N-ligand). A preliminary investigation.
J. Inorg. Biochem., 79: 173-177,
2000.
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| 4)
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Zorzet
S, Bergamo A, Cocchietto M, Sorc A,
Gava B, Alessio E, Iengo E, Sava G.
Lack of in vitro cytotoxicity, associated
to increased G2-M cell fraction
and inhibition of matrigel invasion,
may predict in vivo selective
antimetastasis activity of ruthenium
complexes.
J. Pharmacol. Expl. Ther., 295:
927-933, 2000.
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| 5) |
Cocchietto M, Sava G.
Blood concentration and toxicity of
the antimetastasis agent NAMI-A following
repeated intravenous treatment in mice.
Pharmacol. Toxicol., 87: 193-197,
2000.
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| 6)
|
Sava
G, Cocchietto M.
Blood levels of ruthenium following
repeated treatments with the antimetastatic
compound NAMI-A in healthy Beagle dogs.
In Vivo, 14: 741-744, 2000.
|
| 7) |
Bergamo A, Zorzet S, Gava B, Sorc A,
Alessio E, Iengo E, Sava G.
Effects of NAMI-A and some related ruthenium
complexes on cell viability after short
exposure of tumor cells.
Anti-Cancer Drugs, 11: 667-672,
2000.
|
| 8)
|
Zorzet S, Sorc A,
Casarsa C, Cocchietto M, Sava G.
Pharmacological effects of the ruthenium
complex NAMI-A given orally to CBA mice
with MCa mammary carcinoma.
Metal Based Drugs, 8: 1-7, 2001.
|
| 9) |
Pacor S, Bacac M,
Vadori M, Vismara D, Manfrin A, Sava
G.
Immunostimulating effects of oral lysozyme
on a vaccination treatment with Vibrio
anguillarum.
Far. Ter., XVIII: 51-55,
2001.
|
Copia di ciascun lavoro in Appendice VI.
|
LAVORI
PRESENTATI A CONVEGNI E CONGRESSI |
| 1) |
International Conference on DNA Conformation,
Modification and Recognition in Biomedicine.
Brno, Czech Republic, July 2-5, 2000.
"In vitro
activity pertaining to in vivo
antimetastatic action of ruthenium complexes".
Bergamo A, Cocchietto M, Gava B, Sava
G, Zorzet S.
|
| 2) |
Ibidem.
"NAMI-A: the
first ruthenium-based antimetastatic,
non cytotoxic drug to reach phase I
clinical trials".
Sava G.
|
| 3)
|
VIII
International Congress of the Metastasis
Research Society. London, UK, 24-27
September 2000.
"Activity of
NAMI-A on the metastasis derived, in
vitro cultured metGM cell line".
Pacor S, Bacac M, Sava G, Vadori M,
Vita M, Zabucchi G.
|
| 4)
|
Ibidem.
"ECM binding
and non-cytotoxic metastasis inhibition
by the ruthenium complex NAMI-A".
Sava G, Bergamo A, Cocchietto M, Gava
B, Sorc A, Soranzo MR, Vita F, Zorzet
S.
|
| 5) |
SICCAB - 6th National Meeting.
Rimini (italy), September 25-27, 2000.
"NAMI-A affects
metastasis formation but not host lymphocytes".
Pacor S, Bacac M, Bergamo A, Casarsa
C, Magnarin M, Vadori M, Vita F, Zabucchi
G, Zorzet S, Sava G.
|
| 6)
|
Ibidem.
"Cell cycle
effectsof the metastasis agent NAMI-A".
Pintus G, Tadolini B, Ventura C, Bergamo
A, Cocchietto M, Pacor S, Vadori M,
Zorzet S, Sava G.
|
| 7) |
XV Congress of the Italian Cancer
Society. Turin, October 5-7, 2000.
"In vitro
effects of a new series of bi-nuclear
ruthenium complexes on tumour cells".
Bergamo A, Gava B, Cocchietto M, Alessio
E, Iengo E, Sava G.
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| 8)
|
Ibidem.
"Metastasis
inhibition by NAMI-A: study of the
minimal chemical structure requirement".
Zorzet S, Bergamo A, Cocchietto M,
Gava B, Sorc A, Alessio E, Mestroni
G, Sava G.
|
| 9) |
11th
NCI-EORTC-AACR symposium on new drugs
in cancer therapy. Amsterdam, November
7-10, 2000.
"Host toxicity
of the antimetastasis ruthenium complex
NAMI-A".
Sava G, Bacac M, Beijnen JH, Bergamo
A, Casarsa C, Cocchietto M, Flaibani
A, Pacor S, Schellens JHM, Sorc A, Vadori
M, Vita F, Zorzet S.
|
| 10) |
Ibidem.
"Bioanalysis
of NAMI-A, a ruthenium containing anticancer
agent, using atomic absorption spectrometry
and preliminary pharmacokinetic results
of a phase I trial".
Crul M, vand den Bongard HJGD, van Tellingen
O, Sava G, Giuliani FC, Schellens JHM,
Beijnen JH.
|
| 11) |
Ibidem.
"Pharmaceutical
development of a parenteral lyophylized
formulation of the antimetastatic agent
imidazolium trans-imidazoledimethylsulphoxide-tetrachlororuthenate
(NAMI-A)".
Bouma M, Nuijen B, Sava G, Perbellini
A, Flaibani A, Giuliani F, Talsma H,
Schellens JHM, Beijnen JH.
|
| 12) |
Ibidem.
"Interaction
of NAMI-A with the regulation of cell
cycle progression of tumour cells".
Sava G, Bergamo A, Cocchietto M, Flaibani
A, Gava B, Pintus G, Sorc A, Tadolini
B, Ventura C, Zorzet S.
|
| 13) |
Immunopharmacology
and Immunotherapy Today. Florence,
Italy, november 10-11, 2000.
"Immunostimulating
effects of oral lysozyme on a vaccination
treatment with Vibrio anguillarum".
Pacor S, Bacac M, Casarsa C, Manfrin
A, Vadori M, Vismara D, Sava G.
|
| 14) |
In vitro Models
and Toxicity Mechanisms. Verona,
May 30 - June 1, 2001.
"metGM, a novel
metastatic cell line, as a model for
the study of antimetastasis drugs".
Bacac M, Pacor S, Vadori M, Zabucchi
G, Sava G.
|
| 15) |
International
Conference on New Anticancer Agents.
Athens, 9-12 June 2001, Greece.
"A new in vitro
model for the study of antimetastatic
properties of NAMI-A".
Pacor S, Bacac M, Vadori M, Zabucchi
G, Sava G.
|
| 16) |
Ibidem.
"Effects of
bi-nuclear ruthenium complexes on tumour
cells: knowledge and expectations"
Bergamo A, Gava B, Sorc A, Zorzet S,
Alessio E, Iengo E, Sava G.
|
| 17) |
International
Conference on Invasion and Metastasis.
Athens, 14-17 June 2001, Greece.
"Effects of
NAMI-A on the metastatic potential and
malignancy of Lewis lung carcinoma".
Zorzet S, Sorc A, Turrin C, Bacac M,
Gava B, Vadori M, Sava G.
|
| 18) |
Ibidem.
"In vitro
and in vivo activity of some
ruthenium derivatives of the antimetastatic
compound NAMI-A"
Bergamo A, Gava B, Sorc A, Zorzet S,
Cocchietto M, Castellarin A, Alessio
E, Iengo E, Verders A, Sava G.
|
| 19) |
Ibidem.
"NAMI-A uptake
dependence of cell cycle effects and
of cell cycle protein expression in
KB cells".
Frausin F, Bergamo A, Gava B, Cocchietto
M, Scarcia V, Sava G.
|
| 20) |
Ibidem.
"NAMI-A: a
powerful anti-metastatic agent for solid
tumours, selectively active on metastasis
complexity".
Bergamo A, Cocchietto M, Pintus G, Vita
F, Zorzet S, Sava G.
|
| 21) |
XXX National
Congress of the Italian Pharmacological
Society. Genoa, May 30-June 2, 2001.
"Pharmacological
activity of possible metabolites of
the antimetastasis ruthenium compound
NAMI-A".
Sava G, Bergamo A, Gava B, Zorzet S,
Casarsa C, Cocchietto M, Furlani A,
Scarcia V.
|
| 22) |
Ibidem.
"Ruthenium
cell uptake and pharmacological effects
of the antimetasis complex NAMI-A".
Frausin F, Cocchietto M, Furlani A,
Scarcia V, Bergamo A, Sava G.
|
| 23) |
Ibidem.
"Renal toxicity
of the ruthenium complex NAMI-A".
Vadori M, Bacac M, Sorc A, Casarsa C,
Vita F, Florio C, Pacor S, Zorzet S,
Sava G.
|
| 24) |
Ibidem.
"In vitro effects
of bi-nuclear ruthenium complexes on
tumour cell proliferation and invasion".
Bergamo A, Gava B, Sorc A, Zorzet S,
Alessio E, Iengo E, Sava G.
|
| 25) |
13th
annual Pezcoller Symposium "Cancer
Complexity". Rovereto, Italy,
1-3 June 2000.
"NAMI-A, a
ruthenium-based compound capable of
controlling metastasis growth by interfering
with cancer complexity".
Bergamo A, Pintus G, Tadolini B, Posadino
AM, Sanna B, Debidda M, Bennardini F,
Ventura C, Vita F, Soranzo MR, Frausin
F, Cocchietto M, Furlani A, Scarcia
V, Sava G.
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