Callerio Foundation
NEWS - Zurich, August 22th - 23th, 2014

2nd International Symposium on Functional Metal Complexes that Bind to Biomolecules


The 2nd International Symposium on Functional Metal Complexes that Bind to Biomolecules (3rd Whole Action Meeting of the COST Action CM1105), a two-day meeting took place on August 22-23, 2014 at the Irchel Campus of the University of Zurich as a satellite meeting of EuroBIC 12.

The meeting started on Friday morning and lasted until Saturday evening. The first day was dedicated to Whole Action meeting talks: two senior scientists from each working group presented their latest results.

This session covered multiple topics of which is given here a non-exhaustive selection:

  • the development of metal-organic frameworks (MOFs) as potential candidate capsules for metallodrugs to enhance their efficiency and prevent their biodegradation;
  • the demonstration of the correlation of the kinetics of RNA/RNA interactions with the intrinsic coordination chemistry of the metal ion involved;
  • the coupling of the attractive photophysical and NMR properties of lanthanide ions, with de novo coiled coil ligands, to develop improved MRI and luminescence imaging probes for applications in medicinal diagnostics;
  • the synthesis of Pt(IV) derivatives of cisplatin and oxaliplatin with histone deacetylase inhibitors with the aim to enhance cellular uptake, increase selectivity to cancer cells and to release theanti-proliferative agent inside the cell in addition to the Pt drugs;
  • the use of iClick reactions taking place in the coordination sphere of a metal complex to give mild, quick, and catalysts-free access to a wide range of compounds with very promising anti-parasitic activity.
On the same day, a special session was dedicated to Young Researchers that carried out Short-Term Scientific Missions (STSMs) during the second year of the Action. The STSMs took place as both intra- and inter-WGs exchanges and the researches covered innovative and cutting-edge topics. The presentations dealt with the identification of the target or of the mechanism of action of metallo-drugs, with their interactions with nucleic acid structures (also artificial), with the coupling of light-activated complexes with up-conversion nanoparticles, and with radionuclide therapy with 99mTc compounds. Considering the interest of ESRs for these missions and the quality of the results, STSMs can be regarded as a success of this COST Action.

The afternoon session was followed by a social dinner downtown overlooking the city.
Five individual WG meetings were scheduled for the second day of the meeting, which also included an afternoon poster session. In the WG1 “Protein Targets” meeting, coordinated at Callerio Foundation Onlus, besides the presentation of the latest results, much attention was dedicated to discuss the use of the most appropriate models and tools to guarantee the greatest predictability and transferability of the preclinical in vitro and in vivo models. In addition, each ESR presenting a poster during the common poster session had the opportunity to discuss these results orally with the whole WG.

Overall, the program of the whole conference included ample time for discussion of on-going and future collaborations.


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