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PROJECT “MICROSPHERE”
Microencapsulated biologically active principles uptaken from Peyer’ s patches (PP)


Lisozima
:
CBA female mice treated by oral gavage with a single dose of 0.8 mg lysozyme (LZ)-FITC/mice, free or microencapsulated (MS LZ), respectively, suspended in distilled water. PP were harvested after 30 and 90 min. 




Antigen
(Vibrio anguillarum-VA):

CBA female mice treated by oral gavage with a single dose of 0.15 mg of VA-FITC/mice, free or microencapsulated (MS VA), respectively, suspended in distilled water. PP were harvested after 15, 30 and 60 min.

CONCLUSIONS. The use of the Microsystem seems to anticipate, intensify and prolong LZ or antigen (VA) uptake in the PP of a mice model, in comparison to oral administration of the free protein or antigen.

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