Antibacterial
LZ is commonly known
for its muramidase activity, mostly
against Gram+ bacteria.
Immunostimolant
LZ is known to be
capable to induce a systemic immunostimulation
after oral administration, in preclinical
experimental models as well as in
clinical trials, independently of
its enzymatic activity.
AGE
Scavenging
(advanced glycation end-products)
LZ binds AGE with high affinity (KD=50
nM), promoting the capture, sequestration
and disposal of toxic AGE formed in
vivo.
AGE
are an heterogeneous group of compounds
which multi-step formation start,
under physiological conditions, by
a non-enzymatic glycation reaction
of reducing sugars and proteins (Maillard
reaction). A sustained formation and
tissue accumulation of AGE, typical
of the chronic hyperglycaemia, induces
structural and functional tissue modifications.
