Callerio Foundation - Hits on anticancer metal-based compound discovery

H I T S on anticancer metal-based compound discovery

Ruthenium-Based Staurosporine Mimics with Anticancer Activity

by E. Meggers, G. E. Atilla-Gokcumen, H. Bregman, J. Maksimoska, S. P. Mulcahy, N. Pagano, D. S. Williams, Synlett 2007, 1177-1189. K. S.M. Smalley, R. Contractor, N. K. Haass, A. N. Kulp, G. E. Atilla-Gokcumen, D. S. Williams, H. Bregman, K. T. Flaherty, M. S. Soengas, E. Meggers, M. Herlyn, Cancer Research 2007, 67, 209-217.

Meggers Laboratory at the Phillips-University of Marburg (Germany)


Organoruthenium complexes which mimic the structure and function of the natural product staurosporine. Binding to the ATP binding site of protein kinases has been verfied by protein crystallography. Some compounds exert strong apoptotic activities in several cancer cell lines. Indications for blocking the interaction between MDM2 and p53 through inhibition of GSK-3ß.

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