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Underbreath
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H
I T S
on
anticancer metal-based compound discovery
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| Ruthenium-Based
Staurosporine Mimics with Anticancer
Activity
|
by
E. Meggers, G. E. Atilla-Gokcumen, H. Bregman,
J. Maksimoska, S. P. Mulcahy, N. Pagano, D.
S. Williams, Synlett 2007, 1177-1189. K. S.M.
Smalley, R. Contractor, N. K. Haass, A. N. Kulp,
G. E. Atilla-Gokcumen, D. S. Williams, H. Bregman,
K. T. Flaherty, M. S. Soengas, E. Meggers, M.
Herlyn, Cancer Research 2007, 67, 209-217.
Meggers Laboratory at the Phillips-University
of Marburg (Germany) |
|
- Organoruthenium complexes which
mimic the structure and function of
the natural product staurosporine.
- Binding to the ATP binding site
of protein kinases has been verfied
by protein crystallography.
- Some compounds exert strong apoptotic
activities in several cancer cell
lines. Indications for blocking the
interaction between MDM2 and p53 through
inhibition of GSK-3ß.
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