HT-29
cells, exposed in vitro to the ruthenium compound
indazolium bis-indazoletetrachlororuthenate
(KP1019, FFC14; top, left), shift the JC-1 stain
to the green fluorescence ( middle), indicating
mitochondrial membrane depolarization, in a
dose-dependent way ( left); correspondingly,
the same cells show apoptotic bodies (A) (right),
evidenced by the Hoechst stain.
Kapitza et al., J.Cancer Res. Clin. Oncol. 2005,
131: 101
Jakupec et al., Int. J. Clin. Pharmacol. Ther.
2005, 43: 595
Galanski et al., Curr. Pharm. Des. 2003, 9:
2078 |
