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Updating
of published results
The articles listed and (whenever possible)
linked in this section do not
necessarily need to originate within
the Callerio Foundation: all relevant
contributions by our visitors will be
considered with due attention.
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Messori
L, Marcon G, Orioli P, Fontani M, Zanello
P, Bergamo A, Sava G, Mura P.
Molecular
structure, solution chemistry and biological
properties of the novel [ImH][trans-IrCl(4)(Im)(DMSO)],
(I) and of the orange form of [(DMSO)(2)H][trans-IrCl(4)(DMSO)(2)],
(II), complexes
J Inorg Biochem 1; 95(1):37-46,
May 2003 |
Bouma
M, Nuijen B, Jansen MT, Sava G, Picotti
F, Flaibani A, Bult A, Beijnen JH.
Development
of a LC method for pharmaceutical quality
control of the antimetastatic ruthenium
complex NAMI-A
J Pharm Biomed Anal 26;
31(2):215-28, Feb 2003 |
Morbidelli
L , Donnini S, Filippi S, Messori L, Piccioli
F, Orioli P, Sava G, Ziche M.
Antiangiogenic
properties of selected ruthenium(III) complexes
that are nitric oxide scavengers
British Journal of Cancer;
88: 1484 – 1491, 2003 |
Akbayeva
DN, Gonsalvi L, Oberhauser W, Peruzzini
M, Vizza F, Brugeller P, Romerosa A, Sava
G, Bergamo A.
Synthesis,
catalytic properties and biological activity
of new water soluble ruthenium cyclopentadienyl
PTA complexes [(C5R5)RuCl(PTA)2] (R= H,
Me; PTA= 1,3,5-triaza-7-phosphaadamantane)
Chem Commun; 264-265,
2003 |
Gianfranco
Pintus, Bruna Tadolini, Anna Maria Posadino,
Bastiano Sanna, Marcella Debidda, Federico
Bennardini, Gianni Sava and Carlo Ventura.
Inhibition
of the MEK/ERK signaling pathway by the
novel antimetastatic agent NAMI-A down regulates
c- myc gene expression and endothelial
cell proliferation
Eur.J Biochem; 269: 5861–5870,
2002 |
Fabiana
Frausin, Moreno Cocchietto, Alberta Bergamo,
Vito Scarcia, Ariella Furlani, Gianni Sava.
Tumour
cell uptake of the metastasis inhibitor
ruthenium complex NAMI-A and its in vitro
effects on KB cells
Cancer
Chemother Pharmacol; 50: 405-411, 2002
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Bergamo
A, Gava B, Alessio E, Mestroni G, Serli
B, Cocchietto M, Zorzet S, Sava G.
Ruthenium-based
NAMI-A type complexes with in vivo selective
metastasis reduction and in vitro invasion
inhibition unrelated to cell cytotoxicity
Int J Oncol; 21(6): 1331-8,
Dec 2002. |
Bouma
M, Nuijen B, Jansen MT, Sava G, Flaibani
A, Bult A, Beijnen JH
Department of Pharmacy and Pharmacology,
Slotervaart Hospital, The Netherlands Cancer
Institute, Louwesweg 6, 1066 EC, Amsterdam,
The Netherlands
A
kinetic study of the chemical stability
of the antimetastatic ruthenium complex
NAMI-A
Int J
Pharm 6;248(1-2):239-46, Nov 2002. |
Bouma
M, Nuijen B, Sava G, Perbellini A, Flaibani
A, van Steenbergen MJ, Talsma H, Kettenes-van
den Bosch JJ, Bult A, Beijnen JH
Department of Pharmacy and Pharmacology,
Slotervaart Hospital/The Netherlands Cancer
Institute, Louwesweg 6, 1066 EC, Amsterdam,
The Netherlands
Pharmaceutical
development of a parenteral lyophilized
formulation of the antimetastatic ruthenium
complex NAMI-A
Int
J Pharm 6;248(1-2):247-59, Nov 2002. |
Bouma
M, Nuijen B, Jansen MT, Sava G, Bult A,
Beijnen JH
Slotervaart Hospital/The Netherlands Cancer
Institute, Department of Pharmacy and Pharmacology,
Louwesweg 6, 1066 EC, Amsterdam, The Netherlands
Photostability
profiles of the experimental antimetastatic
ruthenium complex NAMI-A
J
Pharm Biomed Anal 7;30(4):1287-96, Nov 2002. |
| |
R.
Rossin, S. Zorzet, A. Zanella, C. Turrin,
G. Sava, G. Moschini, A. Perbellini, U.
Mazzi
In
vivo Biodistribution Studies on Hyaluronan
Butyrate by Means of 99mTc Direct
Labelling and YAP Camera
In:
Technetium, Rhenium and Other Metals
in Chemistry and Nuclear Medicine (M. Nicolini,
U. Mazzi Eds.), pp 689-693, SGEditoriali,
Padova, 2002. |
Sabrina
Pacor, Anna Giangaspero, Marina Bacac, Gianni
Sava, Alessandro Tossi
Analysis
of the cytotoxicity of synthetic antimicrobial
peptides on mouse leucocytes: implications
for systemic use
Journal
of Antimicrobial Chemotherapy; 50: 339-348,
2002. |
Moreno
Cocchietto, Nicola Skert, Pier Luigi Nimis
e Gianni Sava
A
review on usnic acid, an interesting natural
compound
NATURWISSENSCHAFTEN;
89:137-146, 2002 |
Angelo
Vacca ,Michele Bruno, Angela Boccarelli,
Mauro Coluccia, Domenico Ribatti, Alberta
Bergamo, Spiridione Garbisa, Luigi Sartor,
Gianni Sava
Inhibition
of endothelial cell functions and of angiogenesis
by the metastasis inhibitor NAMI-A
BRITISH JOURNAL OF CANCER;
86: 993-998, 2002 www.bjcancer.com. |
G.
Sava, A.Bergamo, S. Zorzet, B. Gava, C.
Casarsa, M. Cocchietto, A. Furlani, V. Scarcia,
B. Serli, E. Iengo, E. Alessio, G. Mestroni
Influence
of chemical stability on the activity of
the antimetastasis ruthenium compound NAMI-A
European Journal of Cancer;
Vol: 38, Issue: 3, 2002.
|
S.
Pacor M. Vadori, F. Vita, M. Bacac, M.R.
Soranzo, G. Zabucchi, Sava G.
Isolation
of a murine metastatic cell line and preliminary
test of sensitivity to the anti-metastasis
agent NAMI-A.
Anticancer
Research; 21:2523-2530, 2001.
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S.
Zorzet, A. Sorc, C. Casarsa, M. Cocchietto,
Sava G.
Pharmacological
effects of the ruthenium complex NAMI-A
given orally to CBA mice with MCa mammary
carcinoma.
Metal
Based Drugs; 8:1-7, 2001.
|
A.
Bergamo, S. Zorzet, M. Cocchietto, M.E.
Carotenuto, M. Magnarin, G. Sava.
Tumour
cell uptake G2-M accumulationand cytotoxicity
of NAMI-A on TS/A adenocarcinoma cells.
Anticancer Research;
21:1893-1898, 2001. |
Pacor
S, Bacac M, Vadori M, Vismara D, Manfrin
A, Sava G.
Immunostimulating
effects of oral lysozyme on a vaccination
treatment with Vibrio anguillarum.
Far Ter; XVIII: 51-55,
2001.
|
Zorzet
S, Sorc A, Casarsa C, Cocchietto M, Sava
G.
Pharmacological
effects of the ruthenium complex NAMI-A
given orally to CBA mice with MCa mammary
carcinoma.
Metal
Based Drugs; 8: 1-7, 2001.
|
Bergamo A,
Zorzet S, Gava B, Sorc A, Alessio E, Iengo
E, Sava G.
Effects
of NAMI-A and some related ruthenium complexes
on cell viability after short exposure of
tumor cells.
Anti-Cancer
Drugs; 11: 667-672, 2000.
|
Sava G, Bergamo
A.
Ruthenium-based
compounds and tumour growth control
Int J Oncol; 17: 353-365,
2000.
|
Magnarin
M, Bergamo A, Carotenuto ME, Zorzet S, Sava
G.
Increase
of tumour infiltrating lymphocytes in mice
treated
with antimetastatic doses of NAMI-A
Anticancer Res; 20: 2939-2944,
2000.
|
Alessio E,
Iengo E, Zorzet S, Bergamo A, Coluccia M,
Boccarelli A, Sava G.
Antimetastatic
properties and DNA interactions of the novel
class of dimeric Ru(III) compounds Na2[[(trans-RuCl4(Me2SO)]2(mu-L)]
(L= ditopic, non-chelating aromatic N-ligand).
A preliminary investigation.
J
Inorg Biochem; 79: 173-177, 2000.
|
Zorzet S,
Bergamo A, Cocchietto M, Sorc A, Gava B,
Alessio E, Iengo E, Sava G.
Lack
of in vitro cytotoxicity, associated
to increased G2-M cell fraction
and inhibition of matrigel invasion, may
predict in vivo selective antimetastasis
activity of ruthenium complexes.
J Pharmacol Expl Ther;
295: 927-933, 2000.
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Cocchietto
M, Sava G.
Blood
concentration and toxicity of the antimetastasis
agent NAMI-A following repeated intravenous
treatment in mice
Pharmacol
Toxicol; 87: 193-197, 2000.
|
Sava G, Cocchietto
M.
Blood
levels of ruthenium following repeated treatments
with the antimetastatic compound NAMI-A
in healthy Beagle dogs
In
Vivo; 14: 741-744, 2000.
|
Sava
G, Bergamo A.
Drug
control of solid tumour metastases: a critical
view.
Anticancer
Research; 19: 1117-1124, 1999.
|
Bergamo A,
Gagliardi R, Scarcia V, Furlani A, Alessio
E, Mestroni G, Sava G.
In
vitro cell cycle arrest, in vivo
action on solid metastasizing tumors, and
host toxicity of the antimetastatic drug
NAMI-A and cisplatin.
Journal
of Pharmacology and Experimental Therapeutics;
289: 559-564, 1999.
|
Pacor S,
Gagliardi R, Di Daniel E, Vadori M, Sava
G.
In
vitro down regulation of ICAM-1 and
E-cadherin and in vivo reduction
of lung metastases of TS/A adenocarcinoma
by a lysozyme derivative.
International
Journal of Molecular Medicine; 4: 369-375,
1999.
|
Pacor S,
Gagliardi R, Spessotto P, Zabucchi G, Sava
G.
Paracrine
effects of IL-4 transfection on TS/A adenocarcinoma
cells mediate reduced in vivo growth.
Pathology and Oncology
Research; 5: 110-116, 1999.
|
Sava
G, Capozzi I, Clerici K, Gagliardi R, Alessio
E, Mestroni G.
Pharmacological
control of lung metastases of solid tumours
by a novel ruthenium complex
Clinical
Experimental Metastasis; 16: 371-379, 1998.
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